Home/Schweizer Zeitschrift für Onkologie 01/2024/Advancing precision treatment for GI malignancies

Advancing precision treatment for GI malignancies

Upper GI Keynote-811 Since 2009, trastuzumab combined with chemotherapy has been the standard of care for HER2-positive metastatic gastric cancer (mG) and gastroesophageal junction cancer (GEJ), based on the results of the phase 3 ToGA trial (1). In recent years, integrating tumor-specific antibodies with PD-1 inhibitors, has demonstrated enhanced immune infiltration and T-cell response in preclinical studies, effectively countering tolerogenic dendritic cells (2).

Saskia Hussung24.3.2024
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